{"id":229,"date":"2016-02-06T05:16:32","date_gmt":"2016-02-06T05:16:32","guid":{"rendered":"http:\/\/www.drsandeshgupta.com\/blog\/?p=229"},"modified":"2016-02-06T06:24:14","modified_gmt":"2016-02-06T06:24:14","slug":"acanthosis-nigricans","status":"publish","type":"post","link":"https:\/\/www.drsandeshgupta.com\/blog\/acanthosis-nigricans\/","title":{"rendered":"Acanthosis Nigricans"},"content":{"rendered":"<style>.innercontent ul li{ font-size:16px;}<\/style>\n<p>Acanthosis nigricans is characterized by hyperpigmented, verrucous or velvety plaques which usually appear on flexural surfaces and in intertriginous regions. It is most commonly seen in individuals with insulin resistance states, especially obesity, and less frequently in association with other metabolic disorders, drugs and malignancy and so many patients come for this problem in <strong>Dr Sandesh Gupta&#8217;s Skin and laser clinics<\/strong>. Although hyperinsulinemia, hyperandrogenemia, circulating anti- insulin receptor antibodies, and activating mutations in fibroblast growth factor receotor ( especially for syndromes associated with skeletal dyplasia) have been implicated as causal factors, the precise pathogenesis is not yet known. <a href=\"http:\/\/www.drsandeshgupta.com\/best-dermatologist-in-east-delhi-skin-specialist-in-east-delhi-skin-doctor-in-east-delhi-dermatologist-centre-in-east-delhi-skin-centre-east-delhi.html\" title=\"Dermatologist in Delhi\">Dermatologist in Delhi<\/a> treats it with medicines and peels.<\/p>\n<h2>Specific Investigations<\/h2>\n<ul>\n<li> Document obesity  based on ideal body weight<\/li>\n<li>Determine fasting blood glucose and insulin levels in parallel<\/li>\n<li>Depending on historical clues, screen for other endocrine disease<\/li>\n<li> Consider malignancy; if suspected refer to appropriate specialist for the  best diagnostic procedure <\/li>\n<li> Consider drugs as a cause<\/li>\n<\/ul>\n<h2>First- Line Therapy <\/h2>\n<ul>\n<li>Treat the underlying cause<\/li>\n<\/ul>\n<h2>Second- Line Therapy<\/h2>\n<div class=\"left35\">\n<ul>\n<li>Topical tretinoin and ammonium lactate<\/li>\n<li>Oral metformin E -Topical vitamin A <\/li>\n<\/ul>\n<\/div>\n<div class=\"left35\">\n<ul>\n<li>Topical tazarotene<\/li>\n<li>Topical calcipotriol<\/li>\n<\/ul>\n<\/div>\n<div class=\"clearfix\"><\/div>\n<h2>Third- Line Therapy<\/h2>\n<div class=\"left35\">\n<ul>\n<li>Oral isotretinoin<\/li>\n<li>Oral ketokonazole <\/li>\n<li>Palliative chemotherapy<\/li>\n<li>Cyproheptadine<\/li>\n<li>Dietary fish oil <\/li>\n<\/ul>\n<\/div>\n<div class=\"left35\">\n<ul>\n<li>Oral contraceptives <\/li>\n<li>Dermabrasion<\/li>\n<li>Long- plused alexandrite laser<\/li>\n<li>Continuous wave carbon dioxide laser <\/li>\n<\/ul>\n<\/div>\n<div class=\"clearfix\"><\/div>\n<p>These all treatments are done at <strong>Skin n laser centre<\/strong> effectively by Expert <strong>skin specialists<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acanthosis nigricans is characterized by hyperpigmented, verrucous or velvety plaques which usually appear on flexural surfaces and in intertriginous regions. It is most commonly seen in individuals with insulin resistance states, especially obesity, and less frequently in association with other metabolic disorders, drugs and malignancy and so many patients come for this problem in Dr&#8230; <a title=\"Read more - Acanthosis Nigricans\" class=\"moretag\" href=\"https:\/\/www.drsandeshgupta.com\/blog\/acanthosis-nigricans\/\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":230,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[9],"tags":[],"_links":{"self":[{"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/posts\/229"}],"collection":[{"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/comments?post=229"}],"version-history":[{"count":5,"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/posts\/229\/revisions"}],"predecessor-version":[{"id":245,"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/posts\/229\/revisions\/245"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/media\/230"}],"wp:attachment":[{"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/media?parent=229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/categories?post=229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drsandeshgupta.com\/blog\/wp-json\/wp\/v2\/tags?post=229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}